ScheBo® • M2-PK + Hb™ combo stool test

Combination test from pharmacies for the parallel detection of M2-PK enzyme and human hemoglobin (Hb) in stool for improved colorectal cancer prevention.

Die M2-PK is a modern enzyme biomarker and has been identified as the key enzyme in polyps and intestinal tumours. The enzyme M2-PK is completely independent of the presence of blood in the stool. M2-PK is specific for the altered metabolic activity of cells (direct procedure). Non-bleeding polyps and intestinal tumours are also detected, as the M2-PK is independent of blood.

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An entirely different process is immunological blood in stool detection (iFOB) for the determination of human hemoglobin (Hb). This procedure depends on the presence of a source of bleeding in the intestine (indirect method). The modern immunological blood in stool detection (iFOB) has significant advantages over the outdated biochemical blood-in-stool test (FOB); so-called “guaiac” or “hemoccult” test. The modern immunological blood in stool detection (iFOB) of hemoglobin (Hb) represents a significant improvement over the previously used guaiac test (FOB). Only specific antibodies against human hemoglobin (Hb) used.

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The strength of testing ScheBo^® • M2-PK + Hb™ combination chair test is primarily due to the fact that M2-PK enzyme biomarker- and immunological “blood-in-stool” detection (Hb) Measure completely independent and different things and therefore each makes an additional important contribution to colorectal cancer prevention. Based on combined testing of M2-PK and Hb Is it possible to detect both bleeding and non-bleeding intestinal polyps or tumors.

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Sample material: tiny stool sample

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Benefits of ScheBo^® • M2-PK + Hb™ testing (PZN 0242826):

• No adulteration due to food ingredients
• No special diet required
• A tiny stool sample to send to the laboratory is sufficient

Enzyme biomarker M2-PK for the detection of M2-PK in stool:

• Advanced biomarker
• Key enzyme in polyps and intestinal tumours
• High accuracy enzyme test for M2-PK
• Direct method, as it is specific for the altered metabolic activity of cells
• Independent of blood in the chair
• No false positive results due to hemorrhoids or other bleeding
• Detection of intestinal polyps or tumours that do not bleed

Immunological blood-in-stool test (iFOBt) to detect human hemoglobin (Hb) in stool:

• Indirect procedure, as depends on the presence of blood in the stool
• Modern immunological blood test (Hb) with significant advantages over the conventional biochemical guaiac method (GfOB)
• Use of specific antibodies against human hemoglobin (Hb)
• No false negative results due to antioxidants
• No false positive results due to animal hemoglobin or peroxidase reactions due to food ingredients

The test with the central pharmaceutical number (PZN) 0242826 is only available in pharmacies in Germany. The laboratory costs are also paid with the purchase price; further costs are only the postage for a large letter to send the stool sample to our laboratory.

When should M2-PK + Hb be determined in stool:

• Colorectal cancer screening

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