ScheBo® • 2in1 Quick™ stool test

Combination rapid test for the parallel detection of enzyme M2-PK and human hemoglobin (Hb) in stool for improved colorectal cancer prevention

Die M2-PK is a modern enzyme biomarker and has been identified as the key enzyme in polyps and intestinal tumours. The enzyme M2-PK is completely independent of the presence of blood in the stool. M2-PK is specific for the altered metabolic activity of cells (direct procedure). Non-bleeding polyps and intestinal tumours are also detected, as the M2-PK is independent of blood.

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An entirely different process is immunological blood in stool detection (iFOB) for the determination of human hemoglobin (Hb). This procedure depends on the presence of a source of bleeding in the intestine (indirect method). The modern immunological blood in stool detection (iFOB) has significant advantages over the outdated biochemical blood-in-stool test (FOB); so-called “guaiac” or “hemoccult” test. The modern immunological blood in stool detection (iFOB) of hemoglobin (Hb) represents a significant improvement over the previously used guaiac test (FOB). Only specific antibodies against human hemoglobin (Hb) used.

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The strength of testing ScheBo^® • 2-in-1 Quick™ (M2-PK + Hb) is primarily due to the fact that M2-PK enzyme biomarker- and immunological “blood-in-stool” detection (Hb) Measure completely independent and different things and therefore each makes an additional important contribution to colorectal cancer prevention. Based on combined testing of M2-PK and Hb Is it possible to detect both bleeding and non-bleeding intestinal polyps or tumors.

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Sample material: tiny stool sample
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Benefits of ScheBo^® • 2in1 Quick™ (M2-PK + Hb) testing:

• No adulteration due to food ingredients
• No special diet required
• A tiny stool sample is sufficient
• Test result within a few minutes
• Easy feasibility
• No additional devices required
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Enzyme biomarker M2-PK for the detection of M2-PK in stool:

• Advanced biomarker
• Key enzyme in polyps and intestinal tumours
• High accuracy enzyme test for M2-PK
• Direct method, as it is specific for the altered metabolic activity of cells
• Independent of blood in the chair
• No false positive results due to hemorrhoids or other bleeding
• Detection of intestinal polyps or tumours that do not bleed
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Immunological blood-in-stool test (iFOBt) to detect human hemoglobin (Hb) in stool:

• Indirect procedure, as depends on the presence of blood in the stool
• Modern immunological blood test (Hb) with significant advantages over the conventional biochemical guaiac method (FOB)
• Use of specific antibodies against human hemoglobin (Hb)
• No false negative results due to antioxidants
• No false positive results due to animal hemoglobin or peroxidase reactions due to food ingredients

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As an additional option to the patented M2-PK individual test ScheBo, which is already on the market^® • M2-PK Quick™ can the registered doctor take the ScheBo test^® • Now use 2in1 Quick™ (M2-PK + Hb) in his own practice and bill as an IGEL benefit. In addition, the M2-PK individual test is still available as a quantitative measurement by a laboratory specialist.

When should M2-PK + Hb be determined in stool:

• Colorectal cancer screening

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